The results showed that B-ALL patients had lower plasma concentrations of these proteins compared to those of the control group (Fig 4): (B-ALL patients vs controls) PGCA 106.7 ± 4.844 ng/mL vs 127.6 ± 4.985 ng/mL, FETUA 184.7 ± 3.111 μg/mL vs 245.2 ± 11.14 μg/mL, F13A 10.68 ± 0.4860 μg/mL vs 12.48 ± 0.3921 μg/mL and gelsolin 148.4 ± 3.005 μg/mL vs 193.7 ± 5.673 μg/mL (data shown in supporting information S5 Table). This evidence concerns the gene F13A1 and acute lymphoblastic leukemia.