S100A8 and Sepsis: Oxidized S100A8 is a known inhibitor of mast cell degranulation and FcεR-crosslinking-induced cytokine secretion [31, 33, 47, 61], and at least two studies indicate that it has an anti-inflammatory role in acute asthma and sepsis [33, 52], which is attributed to inhibition of inflammatory pathways mediated by ROS.