PTH and Bartsocas-Papas syndrome 1: Considering that SNV rs7125774 is located at approximately 100 kb upstream of the PTH gene, it potentially might regulate PTH gene expression through intergenic transcription and, according to our data, may influence the response of BPs treatment, although the actual molecular mechanism requires further investigation in order to understand whether the correlation is caused by the effects of genetic variance on bone turnover or includes BPs metabolism pathways.