According to the results of the analysis of the association of single polymorphic variants of genes involved in the metabolism of BPs, four informative genetic markers statistically significantly associated with the effectiveness of antiresorptive therapy were identified: SOST rs1234612, PTH rs7125774, FDPS rs2297480, GGPS1 rs10925503. This evidence concerns the gene PTH and Bartsocas-Papas syndrome 1.