NR1H4 and infection: However, the analyses of the first series of microarrays, following HepaRG infection with the adenovirus containing the control siRNA (targeting the non human gene Luciferase) or the specific siRNA targeting FXR, revealed that several pathways, in particular the one related to bile acid metabolism, were severely affected by the control adenovirus, precluding any rigourous analyses of the results with the specific siRNA.