Of the 158 differentially expressed genes associated with IS‐SM many were in pro‐inflammatory pathways including T‐cell receptor signaling (CD3E, TRAT1, ICOS, ITK, AKT3, PRKCQ, KCNA3), chemokine signaling (GRK4, CCR4, CCR8, AKT3 ITK, GPR15), cytokine–cytokine receptor interaction (IL7R, CCR4, CCR8), adipocytokine signaling (AKT3, PRKCQ, KCNA3), hypertension (GRK4), and tight junction pathways (CASK, AKT3). The gene discussed is ICOS; the disease is hypertensive disorder.