Of the 158 differentially expressed genes associated with IS‐SM many were in pro‐inflammatory pathways including T‐cell receptor signaling (CD3E, TRAT1, ICOS, ITK, AKT3, PRKCQ, KCNA3), chemokine signaling (GRK4, CCR4, CCR8, AKT3 ITK, GPR15), cytokine–cytokine receptor interaction (IL7R, CCR4, CCR8), adipocytokine signaling (AKT3, PRKCQ, KCNA3), hypertension (GRK4), and tight junction pathways (CASK, AKT3). The gene discussed is GRK4; the disease is Hypertension.