RBM3 and neurodegenerative disease: In primary neurons and cortical organotypic slice cultures, mild hypothermia markedly increased RBM3 expression and rescued neuronal cells from forced apoptosis.17, 18, 19 In Alzheimer‐type and prion‐infected mouse models, RBM3 was identified as a crucial mediator of hypothermia‐induced neuroprotection,13 revealing that RBM3 induction/overexpression may provide protection not only in cases of acute brain injury but also in neurodegenerative diseases.