EPHX2 and neurodegenerative disease: Under physiological conditions, sEH is an enzyme with the C‐terminal EH activity and N‐terminal PT activity.1, 2 During the past decade, ample evidence indicates that the EH activity of sEH is involved in the development of cardiovascular diseases, inflammatory diseases and neurodegenerative diseases.3, 4, 5, 6, 7, 8, 37 Inhibition of EH activity of sEH results in the accumulation of EETs, which subsequently provide protection against the pathological insults of cardiovascular diseases in vitro and in vivo.