Then, a colony assay revealed that the inhibition of P38 MAPK signaling in the recipient cells treated with SB203580 (5 μmol/L) significantly decreased the colony numbers of the HK1 and HONE1 cells treated with the CNE1‐LMP1 cell‐derived EVs (Figure 5F,G), which indicated that inhibiting P38 activity can restore the radiosensitivity of NPC cells transformed by LMP1‐positive EVs. This evidence concerns the gene PDLIM7 and nasopharyngeal carcinoma.