For instance, the blocking of exosomal LMP1 secretion caused downstream intracellular NF‐κB overstimulation within cells.37 Besides, the transfer of LMP1‐containing EVs in naive recipient cells leads to the activation of PI3K/Akt and MAPK/ERK signaling pathways.27These experiments suggest that EVs containing LMP1 have an important impact on intercellular communication under the environment of viral infection and may promote the carcinogenic effect of EBV. Here, NFKB1 is linked to viral infectious disease.