In conclusion, this study confirmed that EVs derived from LMP1‐positive NPC cells could confer radioresistance to recipient NPC cells by activating P38 MAPK signaling, which suggested that a small proportion of cells expressing LMP1 could enhance the radioresistance of NPC cells through potentially impacting the infected host and also modulating the tumor microenvironment. Here, PDLIM7 is linked to nasopharyngeal carcinoma.