CD274 and neoplasm: Moreover, head and neck cancer is an immunosuppressive tumor, with a lower lymphocyte count than those found in healthy participants.30 Programmed cell death‐1 ligand was found to be expressed in up to 60% of patients with head and neck cancer, leading to impaired natural killer cell activity and poor antigen‐presenting function.30, 31 Development of anti‐PD‐1/PD‐L1 agents might be a novel way to modify the standard treatment of head and neck cancer.