In mouse models of cancer‐induced cachexia, it has been demonstrated that both activin A and IL‐6 are contributing, and neutralizing each axis reverses the muscle wasting.5, 11, 12, 13, 14, 27, 35, 36, 37, 38, 39 Here, we show for the first time that intratumoural activin A signalling promotes IL‐6 secretion from the cancer cells, thus demonstrating a direct link between the two factors. Here, IL6 is linked to cancer.