We have previously found that the CM from TOV21G cells accelerates autophagy in other cells and have largely attributed this effect to their secretion of IL‐6.10 TOV21G cells are known to have an activating KRAS mutation, and this has been shown to be important for IL‐6 production, especially in murine lung cancer models.29, 30 We therefore wanted to establish whether activated KRAS was a major contributor to the IL‐6 production in our model system. This evidence concerns the gene IL6 and lung cancer.