Our current work has added NMSC to the wide spectrum of cancers in which Sam68 expression is significantly elevated and correlates with tumor progression, including colon cancer,14, 18 adult myeloid leukemia,32 oral tongue cancer,15 breast cancer,16 renal cell carcinoma,17 and now, nonmelanoma skin cancer (this study). This evidence concerns the gene KHDRBS1 and hereditary clear cell renal cell carcinoma.