Our recent studies reveal that Src‐associated substrate during mitosis of 68 kDa (Sam68) is an early‐onset and key effector of the response to DNA damage.12, 13, 14 Elevated expression of Sam68 occurs in multiple types of cancers and also correlates with tumor progression.14, 15, 16, 17, 18 Sam68 is ubiquitously expressed in many tissues including the skin 19; however, the significance of Sam68 in skin cancer development and survival has not yet been examined. This evidence concerns the gene KHDRBS1 and cancer.