Our recent studies reveal that Src‐associated substrate during mitosis of 68 kDa (Sam68) is an early‐onset and key effector of the response to DNA damage.12, 13, 14 Elevated expression of Sam68 occurs in multiple types of cancers and also correlates with tumor progression.14, 15, 16, 17, 18 Sam68 is ubiquitously expressed in many tissues including the skin 19; however, the significance of Sam68 in skin cancer development and survival has not yet been examined. The gene discussed is KHDRBS1; the disease is neoplasm.