NFKB1 and neoplasm: We recently reported that Sam68 is an important early DNA damage signaling molecule that regulates DNA damage‐induced activation of poly(ADP‐ribose) polymerase 1 (PARP1) thus fulfilling an essential function in DNA repair and NF‐κB activation signaling pathways.12, 13, 14 As tumor cells generally acquire enhanced DNA repair activities to overcome the intrinsic DNA damage that frequently occurs during rapid proliferation, we sought to examine whether elevated levels of Sam68 in NMSC are essential for the cellular responses to DNA damage.