In a study recently published in Cancer Research, titled “PAK4 Phosphorylates Fumarase and Blocks TGFβ-Induced Cell Growth Arrest in Lung Cancer Cells”, Chen et al. [9] uncovered a novel mechanism for the regulation of H3K36me2 by p38/FH axis, and demonstrated that the metabolic effect of FH on transcriptional regulation is closely related to the cellular response to TGFβ signaling in lung cancer. The gene discussed is FH; the disease is cancer.