In a study recently published in Cancer Research, titled “PAK4 Phosphorylates Fumarase and Blocks TGFβ-Induced Cell Growth Arrest in Lung Cancer Cells”, Chen et al. [9] uncovered a novel mechanism for the regulation of H3K36me2 by p38/FH axis, and demonstrated that the metabolic effect of FH on transcriptional regulation is closely related to the cellular response to TGFβ signaling in lung cancer. This evidence concerns the gene PAK4 and lung carcinoma.