Appearance of the more committed progenitors of glioma CSCs will be confirmed by the attenuation of embryonic (Oct4, Sox2, Nestin) and adult stem cell markers (CD133, CD44, CD15), and upregulation of the progenitor cell markers (PSA-NCAM and Doublecortin) and oligodendrocyte terminal differentiation markers of (ASCL1, OLIG2, DLL3), astrocytes (GFAP), neurons (β-tubulin III, SYT1 and SLC12A5), and markers of inflamed astroglial cells (SERPINE1, TGFB1, RELB). This evidence concerns the gene NES and central nervous system cancer.