The isolation and characterization of glioma CSCs is complicated by the absence of universal phenotypic markers, but a number of candidate proteins have been proposed for its role: СD133 [32], CD44 [33], CD49f [34], Musashi-1 [35], Nestin [36], Nanog [37], Oct4 [38] and Sox2 [39]. This evidence concerns the gene SOX2 and glioma.