Viart and collaborators treated nasal epithelial cells from CF patients with miRNA-binding blocker oligonucleotides (MBBOs) specifically designed to bind the MREs of several CFTR-targeting miRNAs (including miR-101 and miR-145) and found a significant increase in CFTR expression and function [18]. The gene discussed is CFTR; the disease is cystic fibrosis.