To investigate the effect of uPAR knockdown via a pharmacologic agent on cetuximab-resistant OSCC cells, we chose to focus on resveratrol (3,4′,5-trihydroxystilbene), a naturally occurring compound with anti-cancer effects26–31 found in a variety of fruits and plants32 that has previously been shown to potently downregulate uPAR expression, as a therapeutic strategy for targeting cetuximab-resistant OSCC cells. This evidence concerns the gene PLAUR and cancer.