The significance of normalization of the remaining 9 proteins by GC (CCDC80, CNDP1, ANGT, CRDL1, SHBG, IGFBP2, IGFBP3, IGFBP5, ApoL1) and further decrease in AGER, CNTN4 and OMD by GC remains unclear. Here, IGFBP5 is linked to occult macular dystrophy.