CXCR4 and leukemia: A significantly higher CXCR4 RFI was detected on the surface of leukemia cells in the FLT3-ITD mutated AML group (9.24 ± 5.51, mean ± SD) than in the FLT3-wt group (5.72 ± 4.44, P ≤ 0.0001, Fig. 1C).