To identify the involvement of Akt/survivin axis in response to ESW on myocardium in the acute DOX-induced cardiomyopathy model, we evaluated the levels of Akt phosphorylation and survivin in heart tissues of the control, YM155, DOX, ESW + DOX, and YM155 + ESW + DOX groups by immunohistochemical staining or Western blot. The gene discussed is AKT1; the disease is cardiomyopathy.