NOTCH3 and Marfan syndrome: The evidence that NOTCH3 mRNA levels are not modified in BAV compared to control tissues while in Marfan syndrome and TAV aortic specimens they are even increased, does not rule out the possibility that NOTCH3 activation by proteolytic cleavage that leads to NOTCH-activated signaling pathway is impaired and/or not working in the different aneurysmatic pathologies.