CD8A and melanoma: We have shown that Nucl-TAP-mediated TAP downregulation in melanoma and renal tumor cell lines downregulated TAP mRNA (Fig. 6a) and HLA expression (Fig. 6b, c), and induced the presentation of the previously described LRPAP1-derived peptide that was recognized by CD8+ T cells transduced with the corresponding TCR-expressing lentivirus (Fig. 6d, e).