CD8A and neoplasm: Furthermore, incubation of tumor cells in vitro with Nucl-TAP led to the presentation of a previously described TAP downregulation specific Kb-restricted epitope (Fig. 1c), and CD8+ T cells isolated from tumor-bearing mice treated with Nucl-TAP, but not Nucl-Ctrl, siRNA recognized DC pulsed with either an Kb or Qa-1b restricted TAP downregulation-induced peptide (Fig. 4i).