CD4 and neoplasm: No evidence of toxicity was observed in 4T1 tumor-bearing mice treated six times with Nucl-TAP in terms of changes in organ weight (Fig. 5a),CD4+/CD8+ cell ratio in the spleen (Fig. 5b), activation markers of CD4+ and CD8+ T cells (Fig. 5c), hematology parameters (Supplementary Table 1), serum cytokines, despite considerable mouse-to-mouse variation (Fig. 5d), or liver damage as determined by measuring alanine transaminase (ALT) or aspartate transaminase (AST) levels in the circulation (Fig. 5e).