Nucl-TAP treatment inhibited local tumor growth (Fig. 3d) and reduced metastasis (Supplementary Fig. 3d, e) in an orthotopic model for pancreatic cancer19 that was comparable to treatment with Minnelide (Fig. 3e and Supplementary Fig. 4e), a best-in-class therapeutic agent in this model20. The gene discussed is UACA; the disease is neoplasm.