Consistent with the shared and polyclonal nature of TAP downregulation-induced antigens, CD8+ T cells isolated from Nucl-TAP treated MC38 tumor-bearing mice recognized in vitro Nucl-TAP-treated RMA tumor cells (Fig. 4h), DC2.4 cells pulsed with the Kb-restricted TRH4 peptide as well as the TAP downregulation-induced Qa-1b-restricted FAP peptide24 (Fig. 4i), and when transferred to mice inhibited the growth of TAP-deficient RMA-S tumor cells (Fig. 4j). The gene discussed is CD8A; the disease is neoplasm.