JDP2 and neoplasm: By contrast, silencing JDP2 via a short interfering RNA (siRNA), incorporated into dioleoylphosphatidylcholine (DOPC) nanoliposomes, dramatically enhanced the anti-tumor effect of Topotecan, resulting in a lower growth rate of tumor and GSH levels, but higher ROS levels and apoptosis-positive cells in the tumors (Fig. 9a–d).