While most gene sets did not show significant differential responses to increasing concentrations DEX and were highly preserved between PTSD- and PTSD+ participants (e.g., cell cycle, apoptosis, TLR cascades), several other gene sets showed differential transcriptional responses to DEX between PTSD+ and PTSD- participants, including norepinephrine neurotransmitter release, glucocorticoid biosynthesis and IL-1, IL-6 and IL-7 signaling pathways (Zsummary < 2) (Fig. 3c, Table S5). The gene discussed is IL6; the disease is post-traumatic stress disorder.