MECOM and myeloid leukemia: Since evidence in myeloid leukemias implicates N-Ras activation in positively regulating EVI1 expression45 and since EVI1 (located at chromosome 3q26.2) lies within a locus commonly amplified in HGSOC7,9, we next investigated whether overexpression of H-Ras in the transformed FT194 cells could modulate EVI1 protein levels.