TFEB and Parkinson disease: At the striatal level, we obtained a significant astrogliosis between PLP and WT mice, which was reduced in the CMVie/hSyn-mTFEB group, suggesting a decrease in astrogliosis following neuronal expression of TFEB (Figure 6, C and D), reminiscent of what we observed in the A53T–α-syn rat model of PD (Supplemental Figure 1D).