Since TFEB overexpression has been shown to be neuroprotective against AAV-mediated WT α-syn overexpression in rats (23), we first aimed at extending this observation through the assessment of the effects of increasing the ALP through TFEB overexpression in a rat model of PD based, this time, on the overexpression of human mutated A53T–α-syn. The gene discussed is TFEB; the disease is Parkinson disease.