Numerous studies highlight lysosomal impairment as a key player in the pathogenesis of synucleinopathies such as PD and MSA (40, 41), and several therapeutic strategies based on ALP component overexpression, such as LAMP-2A (42) or Beclin-1 (43), have been used to increase autophagy machinery in experimental models of neurodegenerative diseases (44). The gene discussed is BECN1; the disease is multiple system atrophy.