TFEB and multiple system atrophy: Further supporting this interest, we provide the first evidence to our knowledge that targeting TFEB in a cell-specific manner is crucial in MSA pathology — i.e., oligodendroglial-targeted TFEB, as opposed to neuronal-targeted TFEB, leads to neuroprotective and neurotrophic effects with improvement of α-syn clearance after activation of lysosomal biogenesis in a transgenic MSA mouse model.