TFEB has also been validated as an emerging therapeutic target to enhance lysosomal biogenesis and autophagy in different disorders — such as Alzheimer’s disease, in which its astrocytic expression decreases misfolded Tau spreading (52) — but also for lysosomal storage disorders, such as Pompe Disease (53), as well as for ischemic injury (54), alcoholic liver disease (55, 56), and osteoarthritis (57). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.