The moderate but significant changes in the lipid composition in the kidney with tafazzin deficiency presented as the typical alteration profile of a CL loss and MLCL accumulation, as well as the presence of the plasmenylethanolamine loss and the counterbalancing gain of diacyl PE (Fig 2A and B, Tables 1 and S3) suggest that the mitochondrial respiratory function is possibly impaired to unfavorably influence kidney function. Here, TAFAZZIN is linked to hyperinsulinemic hypoglycemia, familial, 4.