These data were further supported by a study of gene expression in duodenal biopsy specimens from cholera patients from whom acute- and convalescent-phase samples were compared; NF-κB signaling was found to be the most upregulated pathway in acute disease (17), and IL-1β, IL-6, and IL-23 were identified as top upstream regulators during acute infection (16, 17). The gene discussed is IL23A; the disease is vibrio infectious disease.