IL23A and vibrio infectious disease: Because the transcriptome-wide analysis of THP-1 responses suggested that IL23A expression was strongly differentially regulated by exposure to live versus heat-inactivated V. cholerae and because our previous studies from human duodenal tissue samples provided evidence that IL-23 is an important mediator of the innate immune response to acute cholera (17), we conducted further experiments to elucidate the dynamics of IL-23 expression and secretion using our model.