The microRNA and its target were important regulatory mechanism for LINC00511, such as miR-185-3p/E2F1 in breast cancer [21], miR29b-3p/VEGFA in pancreatic cancer [22], miR-15a-3p/Wnt signaling pathway in bladder cancer [23], miR-765/APE1 in osteosarcoma [24] and miR-765/LAMC2 in tongue cancer [25]. The gene discussed is E2F1; the disease is tongue cancer.