The gene targets of miR-224-5p, the only one upregulated in CRC, affect three Gene Ontology (GO) biological processes: cellular monovalent inorganic cation homeostasis (CHP2, MAFG, NEDD4L, SLC4A4), regulation of bi-cellular tight junction assembly (FZD5, NEDD4L), and regulation of pH (CHP2, MAFG, SLC4A4). The gene discussed is FZD5; the disease is colorectal carcinoma.