GSDME and adenocarcinoma: There were 10 out of 13 (76.9%) Apc1638N/+ Gsdme KO and 16 out of 24 (66.7%) Apc1638N/+ Gsdme WT mice with one or more adenocarcinomas in the small intestine, with a median of two adenocarcinomas/mouse (range: 1–3) for the Gsdme KO mice and a median of two adenocarcinomas/mouse (range: 1–9) for the WT mice (Figure 7 and Table S5).