In this study, we aimed to determine the potential tumor-suppressive effects of Gsdme both in a chemically induced and in a genetically modified intestinal cancer mouse model, given the strong evidence that GSDME plays a role in human colorectal cancer [5,9,13] and good, representative mouse models for intestinal cancer are available [18,19,20,21,22,23,24,25,26]. This evidence concerns the gene GSDME and colorectal cancer.