Further, blocking CB1 activity in mice on an obesity-inducing diet not only inhibited the development of obesity and improved glucose homeostasis, as expected, but also decreased intestinal permeability as evidenced by reduced circulating LPS levels in association with decreased adipose tissue inflammation and circulating inflammatory cytokine profile, indicating a decrease in systemic inflammation [21]. The gene discussed is CNR1; the disease is obesity due to melanocortin 4 receptor deficiency.