Thus, CB1 regulation of gut permeability, under the influence of the μB, is another mechanism by which CB1 regulates inflammation in addition to direct proinflammatory effects such as, for example, the stimulation of proinflammatory cytokine release from macrophages, which has developmental consequences for type 2 diabetes [90,91]. The gene discussed is CNR1; the disease is type 2 diabetes mellitus.