TNFRSF8 and neoplasm: c-Rel-dependent regulation of expression of eTreg-associated molecules, such as Integrin α E (Itgae), Tigit, Klrg1, Il1r2, and TNF receptor superfamily member 8 (Tnfrsf8), may contribute to eTreg-mediated anti-tumor functions, rather than immune homeostasis [61].