BECN1 and leukemia: As the scientists showed, both the doxorubicin and vincristine treatment of human leukemia cells led to an increase in the level of S100A8, which was necessary for the formation of the Beclin-1–class III phosphatidylinositol 3-kinase (BECN1-PI3KC3) complex, and thus contributed to enhanced autophagy rate in the result of which the drug resistance developed.