FOXRED1 and pulmonary arterial hypertension: However, Apatean et al. have recently described a clinical case of a female patient, with two variants in the FOXRED1 gene (c.612_615dupACTG (p.Ala206fsX15) and c.874G>A (p.Gly292Arg)) who died at 3 months with severe pulmonary hypertension and lactic acidosis [21].