CTLA4 and neoplasm: We will not cover checkpoint inhibitors that facilitate T-cell anti-tumour responses (e.g., ipilimumab/Yervoy; anti-CTLA-4), or similar approaches to facilitate macrophage anti-tumour responses (i.e., Hu5F9-G4; anti-CD47), or antibodies not directed at cancer cells specifically, such as those that target stroma (BMS-936564/MDX1338/ulocuplumab; anti-CXCR4).