NFE2L2 and colitis: In TNBS-induced colitis model, other investigators demonstrated that the main markers of fibrosis (α-smooth muscle actin, collagen I, TIMP-1, and TGF-β1/Smad signaling) and ROS levels were suppressed by tert-butylhydroquinone (tBHQ), an agonist of Nrf2 [91].