Nrf2 could have a protective role in many autoimmune diseases (i.e., vitiligo, asthma, multiple sclerosis, and systemic lupus erythematosus) since an increased production of reactive immunogenic macromolecules intermediates in these disorders seems closely linked to the loss of several phase II detoxification enzymes regulated by the activation of Nrf2 genes [23,36]. This evidence concerns the gene NFE2L2 and multiple sclerosis.