In 2006, for the first time, Khor et al. showed in an experimental dextran sulfate sodium (DSS)-induced colitis model that Nrf2 knockout (KO) mice (Nrf2−/−) were more susceptible to acquiring histological features of colitis (such as a short length of the colon and rectal bleeding) compared to Nrf2 wild-type (WT) mice (Nrf2+/+). The gene discussed is NFE2L2; the disease is colitis.