NFE2L2 and colorectal carcinoma: For this reason, nowadays, many Nrf2 activators of both natural (i.e., sulforaphane, curcumin, resveratrol, kahweol, lycopene, carnosol) [131,132,133,134,135,136] and synthetic (i.e., oltipraz, dimethyl fumarate) origin are constantly tested in order to discover new effective treatments for CRC [137,138,139,140,141].