Next, we assessed the associations between 25(OH)D (per 24.96 nmol/L) with CRC risk, stratified by genotypes of SNPs in the genes that were identified in the step above as potentially modifying the association of 25(OH)D with CRC risk (CYP27B1, GC, ARID1A, CARM1, CHAF1A, SMARCA2, and IL10;Supplementary Table S9). The gene discussed is CHAF1A; the disease is colorectal carcinoma.