VDR and colorectal neoplasm: Observational and RCT data suggest a potential vitamin D-colorectal neoplasms risk association is modified by polymorphisms in the vitamin D receptor (VDR) [10,16,17] and the vitamin D-binding protein gene (GC) [18]; however, only a few single nucleotide polymorphisms (SNPs) and a limited number of related pathways were considered.