VDR and colorectal carcinoma: We examined the associations between SNPs in the genes involved in vitamin D metabolism (genes = 9, SNPs = 274), mineral homeostasis and endocrine regulation of 1,25(OH)2D synthesis (genes = 5, SNPs = 58), vitamin D genomic effects including the VDR complex co-activators and co-regulators (genes = 30, SNPs = 538), and two SNPs in the intergenic regions previously associated with circulating 25(OH)D [27] and CRC risk (Supplementary Table S4).