To demonstrate that NIPA is specifically phosphorylated by ALK expression and not by commonly upregulated pathways (i.e., MEK-pathway) in ALCL cells, we analyzed the phosphorylation of NIPA in ALK+ (DEL, TS, JB6) and ALK- (Jurkat, FEPD, Mac-1) ALCL cell lines with regard to the shift of NIPA in electrophoretic mobility. This evidence concerns the gene ALK and anaplastic large cell lymphoma.