Given that (1) CCL 17 and CCL 22 chemoattract Th2 cells and maintain the Th2 immune response [12,13], (2) serum CCL 17 and CCL 22 levels are closely related to the disease activity of AD [14], and (3) Langerhans cells and dermal dendritic cells (DCs) produce prominent CCL 17 and CCL 22 in the skin of AD patients [12,15], we investigated whether IL-31/IL-31RA interaction affects CCL 17 and CCL 22 production in DCs during the development of AD. This evidence concerns the gene IL31RA and Alzheimer disease.