Since Glyteer inhibits IL-4-induced upregulation of IL-31 RA expression and IL-4-induced Ccl 17 and Ccl 22 production in BMDCs, the dual effects of Glyteer on IL-31RA expression and Ccl 17 and Ccl 22 production contribute to its inhibition of Ccl 17 and Ccl 22 production in AD. This evidence concerns the gene IL31 and Alzheimer disease.