APOE and bacterial infectious disease: In response to bacterial infection patrolling monocytes produced a small quantity of pro-inflammatory cytokines, but significant amounts of anti-inflammatory and healing agents such as IL-1 receptor antagonist, IL-10R, apolipoprotein A (ApoA), apolipoprotein E (ApoE), and CXCL16 (C-X-C motif chemokine ligand 16) [39].