We used data collected from the Framingham Heart Study (FHS), a large population-based, multigeneration cohort with long and intensive follow-up that includes data on AD development and structural brain volumes.23 Included in this study were the FHS offspring cohort (also called Generation 2 or Gen 2) and the plasma samples from examination 7 to measure amylin concentrations. Here, IAPP is linked to Alzheimer disease.