Although the mechanism of amylin’s beneficial effects for the brain is still unclear, amylin is a gut-brain axis hormone that is produced by β-cells in the pancreas31 and crosses the blood-brain barrier.4,5,6 The beneficial effects of amylin for AD are likely through binding to the amylin receptor,21 which is one type of G-protein coupled receptor and is composed of the calcitonin receptor combined with different receptor activity–modifying proteins.7,32. Here, CALCR is linked to Alzheimer disease.