After adjusting for age; sex; education; body mass index (BMI), calculated as weight in kilograms divided by height in meters squared; diabetes; CVD; APOE4 genotype; and high-density lipoprotein, we found that extremely high plasma amylin concentration was associated with 2- to 3-fold increased AD incidence during the follow-up compared with low plasma amylin concentration (hazard ratio, 2.51 [95% CI, 1.38-4.57]; P = .003) (Table 3). This evidence concerns the gene APOE and Alzheimer disease.