Using multivariate linear regression analyses after adjusting for age, sex, education, BMI, diabetes, CVD, and APOE4, the largest amylin quintile, Q5, remained positively associated with temporal lobe brain gray matter volume (β = 0.10 [SE, 0.04]; P = .007) (eTable 6 in the Supplement). The gene discussed is APOE; the disease is diabetes mellitus.