IGF1R and tongue squamous cell carcinoma: In 2010, Jiang et al. (28) observed that microRNA-7 could cause the subexpression of the receptor of the IGF1R growth factor in cells of tongue squamous cell carcinoma and could mitigate phosphorylation or activation of the AKT kinase protein, a protein associated with inflammatory processes mediated by cytokines (30), causing a reduction in cell proliferation and an enhancement of apoptosis (28).