However, in this current study, local administration of 4 μg of IGF-I did not induce any histological changes, neither on the BIC or BAD in OVX animals, nor in animals without osteoporosis, suggesting that the 4 μg dose may be very small compared to the 4 IU of GH (equivalent to 1.3 mg of GH). The gene discussed is IGF1; the disease is osteoporosis.