Disintegrin and metalloproteinase 17 (ADAM17) is an ADAM family member that can modulate diseases and process single transmembrane proteins, such as growth factors, chemokines, cytokines, and receptors.13, 14, 15, 16 ADAM17 is overexpressed in several human tumors, such as NPC, prostate, breast, and ovarian cancers.17, 18. This evidence concerns the gene ADAM17 and ovarian cancer.