The NF‐κB signaling pathway can be activated by ADAM17.21, 22 The key role of NF‐κB in stimulating oncogenesis has been widely acknowledged, and carcinogenic or tumor‐promoting factors can induce the activation of NF‐κB.31, 32 Several studies have indicated that NF‐κB as a TF can regulate miRNA expression by binding to miRNA promoters in many tumor cells.33, 34, 35 Similarly, our study found that activated NF‐κB could inhibit the miR‐449b‐3p expression by binding to the miR‐449b‐3p promoter. This evidence concerns the gene NFKB1 and neoplasm.