Disintegrin and metalloproteinase 17 (ADAM17) is an ADAM family member that can modulate diseases and process single transmembrane proteins, such as growth factors, chemokines, cytokines, and receptors.13, 14, 15, 16 ADAM17 is overexpressed in several human tumors, such as NPC, prostate, breast, and ovarian cancers.17, 18. The gene discussed is ADAM17; the disease is ovarian carcinoma.