This phenomenon reflects greater loss of muscle mass in response to declining levels of growth hormone, insulin-related growth factor (IGF-1) and testosterone in men; also, men tend to adapt poorly to muscle tissue loss compared to women.(31,32) Increasing sarcopenia with age is also associated with age-related morphological and functional changes, such as decreased fat-free mass and muscle strength, which lead to sarcopenia.(33,34). The gene discussed is IGF1; the disease is sarcopenia.