Although there are no reports of VEGF-A exon 8 splice isoform expression in the cardiac muscle, the circulating VEGF-Axxx/VEGF-Axxxb isoform balance has been well documented in both coronary artery disease (CAD) and acute myocardial infarction (AMI) [23,24]. The gene discussed is VEGFA; the disease is coronary artery disorder.