PARK7 and Parkinson disease: While most work in this area has been conducted in toxin‐based PD models, which possess comparatively low physiological relevance, the accumulation of pathogenic PD‐linked proteins (α‐synuclein), deficiency of protective PD‐linked proteins (DJ‐1), or the incorporation of PD‐linked mutations (SNCA) similarly result in ROS‐dependent apoptosis in cultured human or rat dopaminergic neurons (Kim et al., 2005; Xu et al., 2002).