In addition to H2O2, O2− clearance in the PD SNc may be diminished due to SOD1 enzymatic dysfunction and aggregation (Trist et al., 2017; Trist, Fifita, et al., 2018; Trist, Hare, & Double, 2018), which is also associated with neuronal copper deficiency and misfolded α‐synuclein in this brain region (Helferich et al., 2015). Here, SOD1 is linked to Parkinson disease.