MCL1 and cancer: Similarly, Luedtke et al. [28] and Caenepeel et al. [29] presented that treatment of many cancer cell lines (A427, MV-4-11, and NCI-H1568, U266B1, THP-1 and U937) with Mcl-1 inhibitors - A-1210477 or AMG 176 lead to increase of Mcl-1 protein level.