CALR and neoplasm: The rationale for radiotherapy is that it improves the response of tumors to ICMs by modulating the expression of molecules on the surface of tumor cells (e.g., major histocompatibility complex-1, calreticulin, PD-L1 [20]), increasing the secretion of pro-inflammatory cytokines (e.g., interferon gamma) and enhancing the recruitment of immune cells (e.g., it releases tumor antigens into the circulation, decreases the tumor interstitial fluid pressure [21], and activates CD8 T-Cells [22]).