The aims of the present study that focused on a homogeneous population of diffuse large B cell lymphoma patients scanned for interim evaluation after immune-chemotherapy were (1) to perform a comprehensive analysis of the time elapsed between the last G-CSF injection and the PET/CT examination on the biodistribution of 18F-FDG , with emphasis on liver, spleen, and bone marrow uptake, and (2) to investigate whether an inversion of the liver to spleen ratio affects the Deauville scoring. Here, CSF3 is linked to diffuse large B-cell lymphoma.