Although regulation of protein stability appears to play a major role in determining GRK2 dosage, changes in mRNA levels of GRK2 have been noted in several pathological conditions, including hypertension, heart hypertrophy, and heart failure [18, 106], in the acute stage of infectious diseases, such as pneumonia and sepsis [107], or in tumoral pathologies [19]. The gene discussed is GRK2; the disease is hypertensive disorder.